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Pheromone desensitization?

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  • Pheromone desensitization?

    Hmm...not sure if this has implications for human pheromones but something to consider!
    Published in Neuron, a high quality publication so the results are probably not just BS (can't always be sure with publications these days...)

    http://naturalsciencenews.com/2016/0...onic-exposure/

    "Researchers have found a neuron in male mice that allows them to detect and respond to female pheromones. Oddly, this type of neuron disappears if males are constantly exposed to female scents. The findings are in a paper just published in the journal Neuron."

    "The research team discovered that the male mice had a unique type of neuron not found in females. This neuronal cell type could detect epitestosterone sulfate, a sex hormone by-product.

    The team also found that if males were constantly exposed to pheromones in female urine, they lost the female-detecting neurons. This changed their behavior; mice without the special neuron type lost interest in female scents. If the males were once again isolated and not exposed to female smells, the neurons showed up again. This shows that environmental conditions are responsible; it’s not an innate sex-determined cell type. The researchers even removed the testes of the male mice and the ovaries of the females. The neurons still behaved the same way, suggesting that the cell type wasn’t directly related to hormones."


    So essentially, overexposure consistently to this female pheromone caused a neuron in the males that detects the pheromone to disappear. But if the males were isolated for a while the neuron re-appeared. Now obviously cross-generalization of this pheromone specific neuron to humans is a stretch, this is in the VNO which humans may not have, and is specific to this one pheromone, but it would be interesting if this may be why some people start losing effects of pheromones on specific people over time? Or even losing self-effects?

    SteveO?
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  • #2
    knowledgeispower Interesting article! I've noticed that some mones just don't seem to impact me as much as when I first used them.

    Copulins... I don't notice much of an impact other than I tend to check out women more. I don't necessarily find "all women attractive" as some research might suggest though.

    Androstenone... When I first used Bad Wolf, I could feel my heart pounding harder with just 3 drops. Now I can wear 20 with no problem.

    Those are just some examples, but I'd believe there is a possibility this mouse article could apply to human. There are reasons they use certain mice and monkeys in research.

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    • #3
      2 ways to avoid desensitization:
      -) less is more
      -) limit mone application (take breaks or use it on special occasion)
      Give more, Expect Less

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      • #4
        Pandatrooper It makes sense. So now, here's what doesn't make sense.

        Let's examine my use of Bad Wolf. I use it maybe once a week, yet I've developed a significant "tolerance" to it. Ever used it? You'd remember if you did...

        Like I said, at first 3 drops was like WHOA! Now at 20 it's like... meh.

        Could it be a tolerance to androstenone in general? I only infrequently use heavy androstenone products, so I don't know.

        Also, see my test for Odyssey13

        https://discoverxs.com/forum/pheromo...s184-odyssey13

        3 sprays multiple effects. Then about a week later 5 sprays and meh.

        Comment


        • #5
          Yes you could be experiencing tolerance to the self-effects. The only time I would think this is a problem is if #1 the self-effects are the only reason you wear the mone and #2 your target is always being exposed to your signature. However if this isn't the case I wouldn't worry much about the self-effects because the mones should still be having effects on others who aren't always exposed to the same signature.

          And yes as pandatrooper said using less is better if this is the case and taking breaks every now and then as well.
          PXS Product Content Spreadsheet: https://goo.gl/q7KVX1
          PXS
          Sprays: Bliss, SOB, Xist, Taboo, Evolve, Cohesion, Dominant Ascend, Exotica, Ascend (with and without cops), Limitless
          Oils: Xist, Cohesion, Desire Me for Men, Massage Oil for Men
          Samples: SOB, Crush, Bliss, Evolve, Thinker, Odyssey, Vibe, Flirt, Barely Legal, Celebrity
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          • #6
            if it works then i don't see why we should keep increasing our doses..

            for example, let's say i have good results from just applying 3 drops of BW, the additional drops i would add for the next time probably would be 4-5 drops max. i would not go further, moreover 20! and every time i felt like i had a heavy kind of mone-session, i take breaks for like 1-2 weeks just to gain back that neutral non-mone system. if you do this,
            not only you have a more effective number of drops to quality session ratio, but also saved some money since your bottle of mones can now be used in a longer period of time.

            Give more, Expect Less

            Comment


            • #7
              Pandatrooper I should have explained something about the 20 drops... I did that one time as an experiment. When I use Bad Wolf, I use less than 6 drops. However, your comments are definitely note worthy.

              Comment


              • #8
                Come to think of it, this is only expected. How many times have you sprayed a fragrance only to think the smell is "dead" after 30 minutes yet 4 hours later a friend walks in and compliments the scent you no longer smell? This happens with olfactory receptors as well as with taste buds. We "desensitize" to repeat exposure and then need a higher and higher dose to get the same sensitization.

                Now luckily our taste buds and olfactory receptors "re"-sensitize quickly, so if for example you have a candle lit in a room and it smells nice, if you leave the room for say 15 minutes and walk back in the scent is magically "back" (although it really never left, your olfactory receptors had to re-sensitize).

                I imagine pheromones work in the same way...which leads me to this crazy idea:

                For maximum efficacy, if you are spending a long time with your target, maybe it is advisable to leave the room every 30-60 minutes for a 10-15 minute break and come back in so the target gets a new "hit".
                Now obviously pheromones work subconsciously to a level, but they still need to be smelled in order to activate the hypothalamus and other brain structures, and I don't think the science is in on what happens if these receptors get desensitized, but it seems like an interesting idea?
                PXS Product Content Spreadsheet: https://goo.gl/q7KVX1
                PXS
                Sprays: Bliss, SOB, Xist, Taboo, Evolve, Cohesion, Dominant Ascend, Exotica, Ascend (with and without cops), Limitless
                Oils: Xist, Cohesion, Desire Me for Men, Massage Oil for Men
                Samples: SOB, Crush, Bliss, Evolve, Thinker, Odyssey, Vibe, Flirt, Barely Legal, Celebrity
                AD
                AMMO (1.0), IS, IG, IJ, IH, IO, CTTM 2, TUTH (1.0 and 1.1), p74, p83, p93, p100, Spaceland, MX 297, MX 272, MX 291, Lip Magnet

                Comment


                • #9
                  knowledgeispower Intriguing! I was thinking about something along those lines regarding fallout. As many might say fallout requires time with and time away... perhaps that is another way to accelerate the process doing what you just describe above.

                  Comment


                  • #10
                    Originally posted by Xcc View Post
                    knowledgeispower Intriguing! I was thinking about something along those lines regarding fallout. As many might say fallout requires time with and time away... perhaps that is another way to accelerate the process doing what you just describe above.
                    Yes and quite possibly why "resetters" like Xist need repeated exposures? I think I will try this if I get the right opportunity!
                    PXS Product Content Spreadsheet: https://goo.gl/q7KVX1
                    PXS
                    Sprays: Bliss, SOB, Xist, Taboo, Evolve, Cohesion, Dominant Ascend, Exotica, Ascend (with and without cops), Limitless
                    Oils: Xist, Cohesion, Desire Me for Men, Massage Oil for Men
                    Samples: SOB, Crush, Bliss, Evolve, Thinker, Odyssey, Vibe, Flirt, Barely Legal, Celebrity
                    AD
                    AMMO (1.0), IS, IG, IJ, IH, IO, CTTM 2, TUTH (1.0 and 1.1), p74, p83, p93, p100, Spaceland, MX 297, MX 272, MX 291, Lip Magnet

                    Comment


                    • #11
                      i also do believe it is a tolerance thing. i've seen it here and there on phero forums (pheroums? ) that one should take days off sporadically to ensure tolerance is kept at bay. It would make sense for products like Instand Shine and Bliss to take days off, as these pheromones supposedly influence the SELF as a major part of how they work. I've also seen on pherotruth that one should not find a combo and stay stuck on that combo, and although that statement didn't really hint at tolerance, it might be one of the variables involved.

                      Comment


                      • #12
                        I don't find desensitization to really be an issue. I do often use the technique of temporarily removing myself from my target but not because of desensitization. I do it to anchor the phero effect. You imprint her reaction to you by initial exposure and support that by taking away that which influenced her to begin with. This way she knows that it's YOU who is making her feel that way and not just some random reaction.

                        As far as the dosages some of you have mentioned, I can only say that you shouldn't need more that 2 or 3 drops/sprays of any one product to get a reaction. If it takes 4-5-6 doses, that product is a waste of money. I won't even comment as to how ridiculous 20 drops is. If you want to get the whole room laid with your OD go for it. I'm in it to get ME laid.
                        Brute, Dominant Ascend, Prowl, APi, Evolve spray, PSE spray, XSP74 12.5 mcg, XSP75 12.5 mcg, XSP83 12.5 mcg, XSP86 12.5 mcg, XSP93 12.5 mcg, XSP96 12.5 mcg, XSR29 12.5 mcg, XSR32 12.5 mcg, XSR35 12.5 mcg, XSR36 12.5 mcg XSR37 12.5 mcg, XSR39 12.5 mcg, XSR85 12.5mcg, AndrostAnone 25 mcg, AdrostEnone 5 mcg, DHEA 40 mcg, DHEAS 30 mcg, Androsterone 10 mcg, Epi-Androsterone 10 mcg, Androsterone Sulfate 40 mcg, A1 20 mcg, Alpha Androstenol 40 mcg, Beta Androstenol 50 mcg

                        Comment


                        • #13
                          Originally posted by Scottie2Hottie View Post
                          I don't find desensitization to really be an issue. I do often use the technique of temporarily removing myself from my target but not because of desensitization. I do it to anchor the phero effect. You imprint her reaction to you by initial exposure and support that by taking away that which influenced her to begin with. This way she knows that it's YOU who is making her feel that way and not just some random reaction.

                          As far as the dosages some of you have mentioned, I can only say that you shouldn't need more that 2 or 3 drops/sprays of any one product to get a reaction. If it takes 4-5-6 doses, that product is a waste of money. I won't even comment as to how ridiculous 20 drops is. If you want to get the whole room laid with your OD go for it. I'm in it to get ME laid.
                          It probably is not a huge issue but it's hard to know with the little human research on human pheromones. However considering this has been proven to occur in mice, it is not far fetched that something similar might occur in humans. Just food for thought. It's good to mix up your mones every once in a while to be safe
                          PXS Product Content Spreadsheet: https://goo.gl/q7KVX1
                          PXS
                          Sprays: Bliss, SOB, Xist, Taboo, Evolve, Cohesion, Dominant Ascend, Exotica, Ascend (with and without cops), Limitless
                          Oils: Xist, Cohesion, Desire Me for Men, Massage Oil for Men
                          Samples: SOB, Crush, Bliss, Evolve, Thinker, Odyssey, Vibe, Flirt, Barely Legal, Celebrity
                          AD
                          AMMO (1.0), IS, IG, IJ, IH, IO, CTTM 2, TUTH (1.0 and 1.1), p74, p83, p93, p100, Spaceland, MX 297, MX 272, MX 291, Lip Magnet

                          Comment


                          • #14
                            Commenting on the original post perhaps cheating on a relationship is biologically based. That is, it makes a response only to unique female pheromones in lieu of the familiar biologically natural.

                            if this is the case then men cheating is a natural biologic response. To respond otherwise would be abnormal.
                            Last edited by Scottie2Hottie; 09-22-2017, 08:51 AM.
                            Brute, Dominant Ascend, Prowl, APi, Evolve spray, PSE spray, XSP74 12.5 mcg, XSP75 12.5 mcg, XSP83 12.5 mcg, XSP86 12.5 mcg, XSP93 12.5 mcg, XSP96 12.5 mcg, XSR29 12.5 mcg, XSR32 12.5 mcg, XSR35 12.5 mcg, XSR36 12.5 mcg XSR37 12.5 mcg, XSR39 12.5 mcg, XSR85 12.5mcg, AndrostAnone 25 mcg, AdrostEnone 5 mcg, DHEA 40 mcg, DHEAS 30 mcg, Androsterone 10 mcg, Epi-Androsterone 10 mcg, Androsterone Sulfate 40 mcg, A1 20 mcg, Alpha Androstenol 40 mcg, Beta Androstenol 50 mcg

                            Comment


                            • #15
                              Monogamy is not natural. I believe ducks are the only monogamous animals. Even in biblical times men had numerous wives, and concubines. Good ol days.
                              I've tried much more, but these are my current, or most used mones:
                              Spray- XiSt, Evolve, SOB, Ascend, Celebrity, Cohesion, PSE, P86, P96, P75, P130
                              Oil- XiSt, Taboo, Evolve, Ascend, Api, Voodoo

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                              • #16
                                That's a good topic and great advices about it. I agree that is necessary to take brakes from pheromones..
                                Living in Nordic climate, very cold and humid. Targets Caucasian/blond women, not really much chance to test with black, hispanic or asian. Living in a city, I target mostly 18-40 years old.
                                Pheromone XS: SOB, Xist oil, Love boat, Cohesion oil & spray, Ascend -cops-, Connections, Evolve.
                                Alpha dream: Alpha Maschio.
                                Love Scent : scented Chikara, NPA 15ml.
                                Androtics: A 314 oil (rarely use)
                                Cover cologne: Armani Code

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                                • #17
                                  Intersting,
                                  I was wondering why there are ppl who can digest pheromones and some who will smell it as stinking smell only and they are sensitive to it like a military radar,
                                  so far one of my best friends, a shop owner and a neighbour who will just say what is that smell when I am wearing pheromones

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