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Hmm...not sure if this has implications for human pheromones but something to consider!
Published in Neuron, a high quality publication so the results are probably not just BS (can't always be sure with publications these days...)
http://naturalsciencenews.com/2016/0...onic-exposure/
"Researchers have found a neuron in male mice that allows them to detect and respond to female pheromones. Oddly, this type of neuron disappears if males are constantly exposed to female scents. The findings are in a paper just published in the journal Neuron."
"The research team discovered that the male mice had a unique type of neuron not found in females. This neuronal cell type could detect epitestosterone sulfate, a sex hormone by-product.
The team also found that if males were constantly exposed to pheromones in female urine, they lost the female-detecting neurons. This changed their behavior; mice without the special neuron type lost interest in female scents. If the males were once again isolated and not exposed to female smells, the neurons showed up again. This shows that environmental conditions are responsible; it’s not an innate sex-determined cell type. The researchers even removed the testes of the male mice and the ovaries of the females. The neurons still behaved the same way, suggesting that the cell type wasn’t directly related to hormones."
So essentially, overexposure consistently to this female pheromone caused a neuron in the males that detects the pheromone to disappear. But if the males were isolated for a while the neuron re-appeared. Now obviously cross-generalization of this pheromone specific neuron to humans is a stretch, this is in the VNO which humans may not have, and is specific to this one pheromone, but it would be interesting if this may be why some people start losing effects of pheromones on specific people over time? Or even losing self-effects?
XSteveO?
Published in Neuron, a high quality publication so the results are probably not just BS (can't always be sure with publications these days...)
http://naturalsciencenews.com/2016/0...onic-exposure/
"Researchers have found a neuron in male mice that allows them to detect and respond to female pheromones. Oddly, this type of neuron disappears if males are constantly exposed to female scents. The findings are in a paper just published in the journal Neuron."
"The research team discovered that the male mice had a unique type of neuron not found in females. This neuronal cell type could detect epitestosterone sulfate, a sex hormone by-product.
The team also found that if males were constantly exposed to pheromones in female urine, they lost the female-detecting neurons. This changed their behavior; mice without the special neuron type lost interest in female scents. If the males were once again isolated and not exposed to female smells, the neurons showed up again. This shows that environmental conditions are responsible; it’s not an innate sex-determined cell type. The researchers even removed the testes of the male mice and the ovaries of the females. The neurons still behaved the same way, suggesting that the cell type wasn’t directly related to hormones."
So essentially, overexposure consistently to this female pheromone caused a neuron in the males that detects the pheromone to disappear. But if the males were isolated for a while the neuron re-appeared. Now obviously cross-generalization of this pheromone specific neuron to humans is a stretch, this is in the VNO which humans may not have, and is specific to this one pheromone, but it would be interesting if this may be why some people start losing effects of pheromones on specific people over time? Or even losing self-effects?
XSteveO?
) that one should take days off sporadically to ensure tolerance is kept at bay. It would make sense for products like Instand Shine and Bliss to take days off, as these pheromones supposedly influence the SELF as a major part of how they work. I've also seen on pherotruth that one should not find a combo and stay stuck on that combo, and although that statement didn't really hint at tolerance, it might be one of the variables involved.
Even in biblical times men had numerous wives, and concubines. Good ol days. 
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